Don’t rely on pharmacies to catch drug interactions


When you fill a prescription at your local pharmacy, you assume the medicine you receive is safe and won’t interact badly with other drugs you’re taking.

That’s not an unreasonable assumption, considering that pharmacists enjoy a positive reputation among the public. A recent Gallup poll found that pharmacists are among the most trusted professionals ranking second only to nurses.

But pharmacists’ reputations as patient guardians may be unwarranted. The results of an investigation published by the Chicago Tribune before Christmas showed that patients may be in danger after all.

The paper sent reporters to more than 200 pharmacies in the Chicago area, ranging from small neighborhood drug stores to those operated by large national chains. Fifty-two percent of the pharmacies they visited failed to warn patients that a pair of drugs, if taken together, could result in serious potential harm, even death. The Tribune called its findings “striking evidence of an industry-wide failure that places millions of consumers at risk.”

No doubt the poor practices uncovered in Chicago are common in other places. Twenty years earlier, in 1996, U.S. News & World Report published a lengthy study that found as the Tribune did that pharmacists failed to warn their patients of dangerous interactions. Back then, the magazine sent reporters to pharmacies in seven cities and found that “well over half failed to warn consumers when presented with prescriptions for drugs, that, when taken separately are safe but when taken together can be risky at best and at worst deadly.”

What was striking to me was that in 20 years not much has changed in the pharmacy business, and unaware patients are still at risk. In 1996 a spokesperson for the American Pharmaceutical Association told U.S. News reporters about ongoing financial turmoil in the retail drug business. Chains had begun to crowd out independents, HMOs were cutting their reimbursements, and pharmacists were under greater stress. A spokesman for the American Pharmaceutical Association said the profession was “looking at a re-engineering of the whole profession.”

Fast forward to now. Was there really a re-engineering given what the Tribune found in its investigation last year? Since findings from the two studies are similar, I’m skeptical. A vice president of CVS pharmacy told the Tribune, “There is a very high sense of urgency to pursue this issue and get to the root cause.” My question: Why wasn’t there such urgency 20 years ago?

There still appears to be little protection for patients who have no idea whether a particular combination of drugs they take will kill them. While many pharmacies do have computer programs that alert them when a patient is being prescribed drugs that may interact badly, John Norton, director of public relations for the National Community Pharmacists Association, told me pharmacists sometimes fail to heed the warnings.

They may be suffering from what he called “alert fatigue.” In other words pharmacists get so many alerts that they fail to comprehend them all, and something slips through. As the Tribune found, those slips are far too common.

Where does this leave patients? You should still ask the pharmacist to check your records to make sure a new drug doesn’t interact badly with others you take. You can, of course, ask your doctor. But even they may not know – as I found out.

My doctor continued to prescribe Cipro for traveler’s diarrhea for years even though it reduces the effectiveness of another medication I’ve been taking for decades. I learned about this only recently at an urgent care clinic where a doctor refused to prescribe Cipro because of the possible interaction.

Nor can you always rely on those leaflets put in the bags the pharmacist gives you. The information you get may be supplied by outside vendors, says Larry Sasich, who is the co-founder of Patient Drug News and co-authored the 2005 best selling book, “Worst Pills, Best Pills” with Dr. Sidney Wolfe who headed Public Citizen’s Health Research Group for many years.

Sasich says the best information about when a drug should not be used can be found on a drug’s FDA-approved professional product label on the DailyMed website ( sponsored by the National Library of Medicine. At the end of each label is the “Medication Guide” the FDA requires for some 200 drugs – many heavily advertised. The agency requires those labels if it believes information is necessary to prevent serious adverse side effects and when patients need to know about any known and serious side effects.

You can also ask the pharmacist for the professional product label. I asked mine for Cipro’s label. He handed me a tiny, tightly wrapped packet, and said, “You’re not supposed to see this unless you ask.”

My advice: Ask!

What problems have you or a family member had with drug interactions? Write to Trudy at [email protected].

By Trudy Lieberman

Rural Health News Service

Submitted by Rural Health News Service.

No posts to display